发给老马备查:
8 F/ _5 v3 L; {) v% c6 @7 h' t1 X滴水察海(69304838) 15:23:230 ~$ y. N4 M v( D+ J
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱+ D4 P E" c. A O1 T% ]
吉非替尼和S-1连用的依据
( u) r+ D! N4 ]5 O+ B" S, l vGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
+ c; ~( N- R+ @+ I0 X; T是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达/ [% `, T* b! X S5 A+ |
这样是不是推理出,耐药后,可以用S-1和培美了?
7 m7 n& K* k/ l2 M; U& v) N3 b% m结论:
) L8 z2 ]+ |5 ?$ i" `8 q如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |