发给老马备查:, B: l4 S+ i! {. u+ o# \
滴水察海(69304838) 15:23:23
8 h6 U2 o8 e1 I$ s$ ?; x1 i老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
- C) w2 u4 ]. ^5 D9 [吉非替尼和S-1连用的依据
: ~- }6 w, D: J# P8 z$ v+ ZGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.. \1 [: w; X& N% N4 ^" { E
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达" Y0 |) O; N: u( k' K
这样是不是推理出,耐药后,可以用S-1和培美了?1 |# b/ _) d/ c( l! a
结论:: L2 d5 `' d/ {) S* s
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |