发给老马备查:
- a4 Q1 J5 d9 l" D' P' t滴水察海(69304838) 15:23:235 ^4 S4 |' e) T. A1 w) n+ K
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
x$ M/ t( ~6 V; |7 F- H& \0 M$ L吉非替尼和S-1连用的依据
, R* y! D, d0 ^- b+ KGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
( q+ i* h, a4 D b) \9 y是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
8 m( O; G5 U4 [. K这样是不是推理出,耐药后,可以用S-1和培美了?
: B3 i3 l2 g* n3 j8 ]" s1 B结论:1 {- K+ s# X/ x" [; T, N9 t
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |