看见一个 Expert Review of Anticancer Therapy。你们前面用依维莫斯，血、肝肾功能还好。下一步是否考虑索拉非尼+依维莫斯。供你参考。
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V6 K' z' M ~, n2 x! tCurrently available feasibility data for possible combination strategies.
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% ` x1 n* _' \0 E' _Combination Feasibility according to preliminary data
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Bevacizumab + sorafenib Yes, reduced dose
- C. \1 y; P/ `$ z$ P. G9 }5 RBevacizumab + sunitinib† No ; Q$ W( |1 Z: c _4 }" I8 k; c
Bevacizumab + temsirolimus Yes
- @/ |% w( t- KBevacizumab + everolimus Yes
+ U7 w) u% \/ K( tSorafenib + sunitinib ? H1 B: z2 f; q- A# @
Sorafenib + temsirolimus Yes, reduced dose 0 t% {/ {$ I/ g3 r, @# H$ v( ^+ k
Sorafenib + everolimus Yes, reduced dose . y4 X ~/ p+ v) W7 _; c
Sunitinib + temsirolimus† No
" Q. |: u: ?5 u1 h' zSunitinib + everolimus ? % S, h, h# P: }8 i
Temsirolimus + everolimus ?
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†Led to US FDA warning.5 p6 u" G7 E2 _0 ?; s' ]( b9 d1 Q
?: As yet unattempted combination.
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